As with all premier textbooks, the time from actual publication to the release of a new edition creates a gap in the publication of information concerning recent changes in standard clinical practice. In the case of multiple sclerosis, which is rapidly changing and evolving, this is even more apparent. Given the varied expertise and clinical...

The fast pace of clinical research and the release of evidence-based data creates a challenge for premier textbooks to be completely up to date. As we gain new insight into the science of multiple sclerosis, this is even more apparent. This chapter update will shed new light on the pathophysiology and progression of multiple sclerosis...