*
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1234
Conventional synthetic DMARDs [e.g. methotrexate(MTX)]
Tumor necrosis factor targeted monoclonal antibodies (mAB) (e.g. infliximab)
CD-20 directed mABs (e.g. rituximab)
CTLA-4 targeted therapy (e.g. abatacept)
Il-6 targeted mABs (e.g.tocilizumab)
JAK inhibitors (e.g. tofacitinib)
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1234
Serum-based markers of inflammation (e.g. ESR, CRP, RF)
X-ray imaging
MRI and/or ultrasound imaging
Joint swelling/tenderness
Clinical RA scores (e.g. DAS28, CDAI)
Patient reported physical function and global assessment
Patient reported pain, fatigue and quality of life
*
*
*
1234
Patient intolerant or refractory to MTX monotherapy
Patient intolerant or refractory to csDMARD combination therapy
Patient intolerant or refractory to TNF-inhibition therapy (with or without MTX)

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